Ampoule Production

Ampoule Washing, Drying, and Filling and Sealing Production .jpg

Ampoule Washing, Drying, and Filling and Sealing Production

图片1 .jpgProduct Details


 

Introduction of the production line  

ALX series of ampoule washing, drying, and filling and  sealing production  line includes KCQ ultrasonic ampoule washing machine, ASMR sterilizing  dryer, AGFA ampoule filling and sealing machine. They are developed on the advanced technology from BOSCH and B+S and  IMA, they are applicable for  small  volume injection ampoule product production

This proudction line is used for production of  type B ampoules, including ultrasonic water and gas  alternating washing, high  temperature hot air sterilization, multi needle liquid filling and sealing machine.

 

Process

Ampoules unboxing →feeding onto the conveyor belt →water  rinsing → → ultrasonic washing screw feeding → cam lifting→ mechanical arm  turning the ampoule mouth down→ ampoule external rinsing→ 1st flushing with  circulation water with needle inserting into the ampoule→ 2nd flushing with  circulation water with needle inserting into the ampoule→ 1st blowing with  cleaning compressed air with needle inserting into the ampoule→1st flushing with  WFI with needle inserting into the ampoule→2nd blowing with cleaning compressed  air with needle inserting into the ampoule→ 3rd blowing with cleaning compressed  air with needle inserting into the ampoule →ampoule external blowing with  cleaning compressed air, needle withdraw out of the ampoule→ mechanical arm  turning ampoule mouth up→ ampoule out→ preheating→ high temperature  sterilization → cooling→ ampoule delivery→ turn table ampoule feeding → screw  feeding→ filling→ nitrogen  gassing→  ampoule preheating→ ampoule sealing→counting→ ampoule outlet  

 

Parameter of the production line

 

 

Production line  Model

ALX8 Ampoule Washing, Drying, Filling  Production Line

ALX10 Ampoule Washing, Drying, Filling  Production Line

ALX12 Ampoule Washing, Drying, Filling  Production Line

Individual  machine model

KCQ80  

ASMR600/43  

AGFA8

KCQ100  

ASMR600/43  

AGFA10

KCQ120

ASMR600/43

AGFA12

Applicable  size

1-20ml  ampoule

1-10ml  ampoule

1-2ml  ampoule

Production  capacity

1  ml-2ml:24000pcs/hour

5m:  18000pcs/hour

10ml:  12000pcs/hour

20ml:7000pcs/hour

1  ml-2ml:28000pcs/hour

5ml:  21000pcs/hour

10ml:  16000pcs/hour

1  ml-2ml:33000pcs/hour

Filling pump  accuracy

Chinese  pharmacopeia compliance

Breakage  rate

Ampoule washing  machine≤1%, filling machine≤1%

Sterilization  capacity

Ampoule internal  temperature≥320℃,  sterilization time≥5min

Qualified  rate

≥99%

WFI

0.25 Mpa 50℃ 0.8  m3/h

0.25 Mpa   50℃   1  m3/h

0.25 Mpa 50℃ 1.2 m3/h

Compressed air  

0.4-0.6 Mpa  ≈60m3/h

0.4-0.6 Mpa  ≈75m3/h

0.4-0.6 Mpa ≈90m3/h

Gas consumption  

coal gas: 2  m3/h

LPG gas: 0.4  m3/h

coal gas: 2.5  m3/h

LPG gas: 0.5  m3/h

coal gas: 3  m3/h

LPG gas: 0.6  m3/h

Oxygen  consumption

for coal gas: 1.2  m3/h

for LPG gas:  1.8m3/h

for coal gas: 1.5  m3/h

for LPG gas:  2.2m3/h

for coal gas: 1.8  m3/h

for LPG gas:  2.6m3/h

Machine  noise

≤70dB

Operator  

3  persons

Air absorbtion  

5360 m3/h

Power

63  kW

Dimension  

8900×2600×2500   (mm)

Weight  

~6600  kg

~6700  kg

~6800  kg


Ampoule ultrasonic washing machine

Introduction

Ampoule Ultrasonic washing Machine  (hereinafter referred to as washing machines), this machine is mainly used in  the pharmaceutical industry for small volume ampoule cleaning, it can  automatically complete the production process from ampoule feeding, ultrasonic  cleaning and  external washing, internal  washing to ampoule out.

Ampoules after the washing machine are  with high purity, they comply with GMP requirements.

The machine performance is stable,  reliable, low breakage, production speed can be variable controlled, easy to  operate, can be used as independent machine or   integrated into production line the tunnel sterilizing dryer, filling and  sealing machine.

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Main Technical Parameter


Model

KCQ80

KCQ100

KCQ120

Applicable  size

1-20ml   ampoule

1-10ml   ampoule

1-2ml   ampoule

 Packaging size

Paper carton or  tray width B≤315, length L≤400(see the  following)

capacity

1  ml-2ml:24000pcs/hour

5m:  18000pcs/hour

10ml:  12000pcs/hour

20ml:7000pcs/hour

1  ml-2ml:28000pcs/hour

5ml:  21000pcs/hour

10ml:  16000pcs/hour

1  ml-2ml:33000pcs/hour

Breakage  rate

≤1%

Water  Consumption

0.8 m3/h

Pressure ≥0.25  MPa

1 m3/h

Pressure ≥0.25  MPa

1.2 m3/h

Pressure ≥0.25  MPa

Compressed Air  consumption

60 m3/h

 Pressure ≥0.25 MPa

75 m3/h

Pressure ≥0.25  MPa

90 m3/h

Pressure ≥0.25  MPa

Power

10.45kW

Weight

2100kg

2200kg

2300kg

Dimension  mm

2225×2165×1400

 

Ampoule Tunnel Sterilization  Dryer

Introduction

Ampoule tunnel sterilization dryer is designed and  manufactured by our factory on the base of importing, digesting and absorbing  foreign advanced technology. It is mainly used on the injection linked  production line of pharmaceutical factories. It can continuously dry, sterilize  and remove pyrogen of the washed ampoule or big / small glass medicine ampoule.  Due to using heating of “Hot air laminar flow”, the heating is constant and  even, the sterilization time is short with good sterilization effect, and the  production capability is high. The machine is tunnel  structure, includes preheating zone, high temperature sterilization zone,  cooling zone, it uses the hot circulation air to sterilze the product within a  short period, it is applicable for ampoule, antibiotic vial, oral liquid  production.

 

Main Technical Parameter  

 

Model

ASMR600/43 Tunnel  type Sterilization drier   

Applicable  size

1-20ml   ampoule

Production  capacity

1 ml-2ml  33000pcs/hour

5ml       20000pcs/hour

10ml      16000pcs/hour

20ml      10000pcs/hour

Delivery belt width

560mm

Tunnel air cleaning class

100 class(US standard 209E)

Power Consumption

Installation power: 48.57kw

Electric heating power: 43.2kw

Power

380V 50Hz ( three phase  five wire)

Noise

Less than 70dB

Sterilization temperature

≥320℃

Sterilization time

≥ 5 minutes

Ampoule internal temperature

320℃ ±5

Sterilization quality

Particle and Endotoxin  comply with “Chinese pharmacopeia”  

Breakage rate

<0.01%

Ampoule temperature after cooling

< room temperature++15℃

HEPA Filter

99.997%

Particle test

100 class

Air suction

5000  m3/h

Machine dimension   

(L*W*H)

3180×1560×2350(mm)

sterilzation zone length

800mm

Weight

About 2000  kg

 

Ampoule Filling and Sealing  Machine

Introduction

Ampoule (antibiotic ampoule)  dual-purpose machine is researched and manufactured by our factory, it is a new  type dual-purpose machine with world leading technical level for ampoule filling  and sealing (antibiotic ampoule filling, stopper adding or semi stopper adding).  The ampoule medicine liquid filling and sealing are mainly applicable for  8-needle filling-sealing of 1ml - 20ml; 10-needle filling and sealing is mainly  applicable for 1ml - 5ml (antibiotic ampoule medicine liquid filling, stopper  adding and semi stopper adding is mainly applicable for 2ml - 15ml, 8-needle  filling). Only need to change a little of parts, you can change the production  of antibiotic ampoule to ampoule, or vice versa. The machine is composed of  transmission part, ampoule inlet part, filling part, stopper adding part,  ampoule outlet part and hopper frame, the machine has a compact and simple  structure for easy maintenance. This machine can be either for single machine  production, or for linked production line with ampoule washing machine and  dryer. It is one of the ideal equipment for pharmaceutical factory GMP  reformation and realizing the modernized production.

The table of the filling  machine is step type for easy washing, it has optional peristaltic pump, glass  pump and ceramic piston pump for customer to choose. The application of the  servo motor driving, PLC, frequency converting speed regulation and the  technology coordinating each functional mold with servo motor makes the control  system reach the world advanced level. The ampoule inlet system of this machine  has mesh-belt transition, rotary plate and screw rod structure. This structure  can reduce the ampoule breakage due to direct ampoule inlet to reduce ampoule  contamination; it can efficiently control the ampoule inlet speed to reach  front-rear synchronization; it can reduce screw rod’s friction, raise ampoule  inlet efficiency, ensure reaching the designed production  rate. 

 

Main Technical Parameter



Model

AGFA8

Ampoule filling and sealing  machine

AGFA10

Ampoule filling and sealing  machine

AGFA12

Ampoule filling and sealing  machine

Applicable  size

1-20ml   Ampoule

1-10ml   Ampoule

1-2ml   Ampoule

Production  capacity

1  ml-2ml:24000pcs/hour

5m: 18000pcs/hour

10ml:  12000pcs/hour

20ml:7000pcs/hour

1  ml-2ml:28000pcs/hour

5ml: 21000pcs/hour

10ml:  16000pcs/hour

1  ml-2ml:33000pcs/hour

Gas  consumption

coal gas: 2 m3/h

LPG gas: 0.4  m3/h

coal gas: 2.5 m3/h

LPG gas: 0.5  m3/h

coal gas: 3 m3/h

LPG gas: 0.6  m3/h

Oxygen  consumption

for coal gas: 1.2  m3/h

for LPG gas:  1.8m3/h

for coal gas: 1.5  m3/h

for LPG gas:  2.2m3/h

for coal gas: 1.8  m3/h

for LPG gas:  2.6m3/h

Sealing qualification  rate

99%

No ampoule no filling  rate, ampoule falling, equipment stop rate

100%

Filling pump accuracy  

Comply with Chinese  Pharmacopeia

Qualification  rate

≥98%

Breakage  rate

≤1%

Noise

<70dB

Air suction  

360 m3/h

Power

Ac380V/50Hz

Overall power  

2.4kW

Main quality  

 About 2500 kg

Dimension mm  (L*W*H)

3600×2100×2450


 


 

 

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