Ampoule Washing, Drying, and Filling and Sealing Production
Product Details
Introduction of the production line
ALX series of ampoule washing, drying, and filling and sealing production line includes KCQ ultrasonic ampoule washing machine, ASMR sterilizing dryer, AGFA ampoule filling and sealing machine. They are developed on the advanced technology from BOSCH and B+S and IMA, they are applicable for small volume injection ampoule product production
This proudction line is used for production of type B ampoules, including ultrasonic water and gas alternating washing, high temperature hot air sterilization, multi needle liquid filling and sealing machine.
Process
Ampoules unboxing →feeding onto the conveyor belt →water rinsing → → ultrasonic washing screw feeding → cam lifting→ mechanical arm turning the ampoule mouth down→ ampoule external rinsing→ 1st flushing with circulation water with needle inserting into the ampoule→ 2nd flushing with circulation water with needle inserting into the ampoule→ 1st blowing with cleaning compressed air with needle inserting into the ampoule→1st flushing with WFI with needle inserting into the ampoule→2nd blowing with cleaning compressed air with needle inserting into the ampoule→ 3rd blowing with cleaning compressed air with needle inserting into the ampoule →ampoule external blowing with cleaning compressed air, needle withdraw out of the ampoule→ mechanical arm turning ampoule mouth up→ ampoule out→ preheating→ high temperature sterilization → cooling→ ampoule delivery→ turn table ampoule feeding → screw feeding→ filling→ nitrogen gassing→ ampoule preheating→ ampoule sealing→counting→ ampoule outlet
Parameter of the production line
Production line Model | ALX8 Ampoule Washing, Drying, Filling Production Line | ALX10 Ampoule Washing, Drying, Filling Production Line | ALX12 Ampoule Washing, Drying, Filling Production Line | ||
Individual machine model | KCQ80 ASMR600/43 AGFA8 | KCQ100 ASMR600/43 AGFA10 | KCQ120 ASMR600/43 AGFA12 | ||
Applicable size | 1-20ml ampoule | 1-10ml ampoule | 1-2ml ampoule | ||
Production capacity | 1 ml-2ml:24000pcs/hour5m: 18000pcs/hour10ml: 12000pcs/hour20ml:7000pcs/hour | 1 ml-2ml:28000pcs/hour 5ml: 21000pcs/hour 10ml: 16000pcs/hour | 1 ml-2ml:33000pcs/hour | ||
Filling pump accuracy | Chinese pharmacopeia compliance | ||||
Breakage rate | Ampoule washing machine≤1%, filling machine≤1% | ||||
Sterilization capacity | Ampoule internal temperature≥320℃, sterilization time≥5min | ||||
Qualified rate | ≥99% | ||||
WFI | 0.25 Mpa 50℃ 0.8 m3/h | 0.25 Mpa 50℃ 1 m3/h | 0.25 Mpa 50℃ 1.2 m3/h | ||
Compressed air | 0.4-0.6 Mpa ≈60m3/h | 0.4-0.6 Mpa ≈75m3/h | 0.4-0.6 Mpa ≈90m3/h | ||
Gas consumption | coal gas: 2 m3/h LPG gas: 0.4 m3/h | coal gas: 2.5 m3/h LPG gas: 0.5 m3/h | coal gas: 3 m3/h LPG gas: 0.6 m3/h | ||
Oxygen consumption | for coal gas: 1.2 m3/h for LPG gas: 1.8m3/h | for coal gas: 1.5 m3/h for LPG gas: 2.2m3/h | for coal gas: 1.8 m3/h for LPG gas: 2.6m3/h | ||
Machine noise | ≤70dB | ||||
Operator | 3 persons | ||||
Air absorbtion | 5360 m3/h | ||||
Power | 63 kW | ||||
Dimension | 8900×2600×2500 (mm) | ||||
Weight | ~6600 kg | ~6700 kg | ~6800 kg |
Ampoule ultrasonic washing machine
Introduction
Ampoule Ultrasonic washing Machine (hereinafter referred to as washing machines), this machine is mainly used in the pharmaceutical industry for small volume ampoule cleaning, it can automatically complete the production process from ampoule feeding, ultrasonic cleaning and external washing, internal washing to ampoule out.
Ampoules after the washing machine are with high purity, they comply with GMP requirements.
The machine performance is stable, reliable, low breakage, production speed can be variable controlled, easy to operate, can be used as independent machine or integrated into production line the tunnel sterilizing dryer, filling and sealing machine.
Main Technical Parameter
Model | KCQ80 | KCQ100 | KCQ120 |
Applicable size | 1-20ml ampoule | 1-10ml ampoule | 1-2ml ampoule |
Packaging size | Paper carton or tray width B≤315, length L≤400(see the following) | ||
capacity | 1 ml-2ml:24000pcs/hour 5m: 18000pcs/hour 10ml: 12000pcs/hour 20ml:7000pcs/hour | 1 ml-2ml:28000pcs/hour 5ml: 21000pcs/hour 10ml: 16000pcs/hour | 1 ml-2ml:33000pcs/hour |
Breakage rate | ≤1% | ||
Water Consumption | 0.8 m3/h Pressure ≥0.25 MPa | 1 m3/h Pressure ≥0.25 MPa | 1.2 m3/h Pressure ≥0.25 MPa |
Compressed Air consumption | 60 m3/h Pressure ≥0.25 MPa | 75 m3/h Pressure ≥0.25 MPa | 90 m3/h Pressure ≥0.25 MPa |
Power | 10.45kW | ||
Weight | 2100kg | 2200kg | 2300kg |
Dimension mm | 2225×2165×1400 |
Ampoule Tunnel Sterilization Dryer
Introduction
Ampoule tunnel sterilization dryer is designed and manufactured by our factory on the base of importing, digesting and absorbing foreign advanced technology. It is mainly used on the injection linked production line of pharmaceutical factories. It can continuously dry, sterilize and remove pyrogen of the washed ampoule or big / small glass medicine ampoule. Due to using heating of “Hot air laminar flow”, the heating is constant and even, the sterilization time is short with good sterilization effect, and the production capability is high. The machine is tunnel structure, includes preheating zone, high temperature sterilization zone, cooling zone, it uses the hot circulation air to sterilze the product within a short period, it is applicable for ampoule, antibiotic vial, oral liquid production.
Main Technical Parameter
Model | ASMR600/43 Tunnel type Sterilization drier |
Applicable size | 1-20ml ampoule |
Production capacity | 1 ml-2ml 33000pcs/hour 5ml 20000pcs/hour 10ml 16000pcs/hour 20ml 10000pcs/hour |
Delivery belt width | 560mm |
Tunnel air cleaning class | 100 class(US standard 209E) |
Power Consumption | Installation power: 48.57kw Electric heating power: 43.2kw |
Power | 380V 50Hz ( three phase five wire) |
Noise | Less than 70dB |
Sterilization temperature | ≥320℃ |
Sterilization time | ≥ 5 minutes |
Ampoule internal temperature | 320℃ ±5℃ |
Sterilization quality | Particle and Endotoxin comply with “Chinese pharmacopeia” |
Breakage rate | <0.01% |
Ampoule temperature after cooling | < room temperature++15℃ |
HEPA Filter | 99.997% |
Particle test | 100 class |
Air suction | 5000 m3/h |
Machine dimension (L*W*H) | 3180×1560×2350(mm) |
sterilzation zone length | 800mm |
Weight | About 2000 kg |
Ampoule Filling and Sealing Machine
Introduction
Ampoule (antibiotic ampoule) dual-purpose machine is researched and manufactured by our factory, it is a new type dual-purpose machine with world leading technical level for ampoule filling and sealing (antibiotic ampoule filling, stopper adding or semi stopper adding). The ampoule medicine liquid filling and sealing are mainly applicable for 8-needle filling-sealing of 1ml - 20ml; 10-needle filling and sealing is mainly applicable for 1ml - 5ml (antibiotic ampoule medicine liquid filling, stopper adding and semi stopper adding is mainly applicable for 2ml - 15ml, 8-needle filling). Only need to change a little of parts, you can change the production of antibiotic ampoule to ampoule, or vice versa. The machine is composed of transmission part, ampoule inlet part, filling part, stopper adding part, ampoule outlet part and hopper frame, the machine has a compact and simple structure for easy maintenance. This machine can be either for single machine production, or for linked production line with ampoule washing machine and dryer. It is one of the ideal equipment for pharmaceutical factory GMP reformation and realizing the modernized production.
The table of the filling machine is step type for easy washing, it has optional peristaltic pump, glass pump and ceramic piston pump for customer to choose. The application of the servo motor driving, PLC, frequency converting speed regulation and the technology coordinating each functional mold with servo motor makes the control system reach the world advanced level. The ampoule inlet system of this machine has mesh-belt transition, rotary plate and screw rod structure. This structure can reduce the ampoule breakage due to direct ampoule inlet to reduce ampoule contamination; it can efficiently control the ampoule inlet speed to reach front-rear synchronization; it can reduce screw rod’s friction, raise ampoule inlet efficiency, ensure reaching the designed production rate.
Main Technical Parameter
Model | AGFA8 Ampoule filling and sealing machine | AGFA10 Ampoule filling and sealing machine | AGFA12 Ampoule filling and sealing machine |
Applicable size | 1-20ml Ampoule | 1-10ml Ampoule | 1-2ml Ampoule |
Production capacity | 1 ml-2ml:24000pcs/hour 5m: 18000pcs/hour 10ml: 12000pcs/hour 20ml:7000pcs/hour | 1 ml-2ml:28000pcs/hour 5ml: 21000pcs/hour 10ml: 16000pcs/hour | 1 ml-2ml:33000pcs/hour |
Gas consumption | coal gas: 2 m3/h LPG gas: 0.4 m3/h | coal gas: 2.5 m3/h LPG gas: 0.5 m3/h | coal gas: 3 m3/h LPG gas: 0.6 m3/h |
Oxygen consumption | for coal gas: 1.2 m3/h for LPG gas: 1.8m3/h | for coal gas: 1.5 m3/h for LPG gas: 2.2m3/h | for coal gas: 1.8 m3/h for LPG gas: 2.6m3/h |
Sealing qualification rate | 99% | ||
No ampoule no filling rate, ampoule falling, equipment stop rate | 100% | ||
Filling pump accuracy | Comply with Chinese Pharmacopeia | ||
Qualification rate | ≥98% | ||
Breakage rate | ≤1% | ||
Noise | <70dB | ||
Air suction | 360 m3/h | ||
Power | Ac380V/50Hz | ||
Overall power | 2.4kW | ||
Main quality | About 2500 kg | ||
Dimension mm (L*W*H) | 3600×2100×2450 |
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